Research Resources - All
A variety of research support services are available to assist University of Pittsburgh investigators in advancing their research programs. You can find resources categorically by choosing one of options below or search the entire directory through the keyword search option.
To submit updates, or to request the addition of a resource, please contact Paul Wood at firstname.lastname@example.org or (412) 648-9618.
For Pitt Biomedical Research Facilities' web site search.
View Resources by Category
Genome Editing, Transgenic, and Virus Core (GETV)
The Genome Editing, Transgenic and Virus core (GETV) is dedicated to shepherding projects, from vector design to the establishment and maintenance of valuable transgenic/knockout/knockin lines. The core assists investigators by developing state-of-the-art strategies to solve complex biological problems using transgenic, gene editing and viral vector approaches. Directed by Dr. Kyle Orwig and managed by Dr. Yi Sheng, the core provides technical expertise, advice and services for investigators in the University of Pittsburgh community and beyond. Please see the website or contact us for further information or to schedule a face to face meeting to design and implement your experimental plans.
- Assistance for generating recombinant plasmids;
- Design and implementation of CRISPR/Cas9 technology for in vivo and in vitro work;
- Mouse and rat transgenesis, including transgenic and knockout/knockin techniques using pronuclear injection, ES cell injection/chimera and CRISPR/Cas9-mediated genome editing;
- Lentivirus, adenovirus and adeno-associated virus vectors;
- Cryopreserve or re-derive of valuable transgenic/knockout or other rodent lines using sperm or embryos;
- Additional animal testing and procedures: teratoma and chimera testing to validate putative pluripotent stem cell lines;
- GETV core services are approved by the Institutional Animal Care and Use Committee (IACUC), the recombinant DNA committee, and the environmental health and safety office of the University of Pittsburgh.
Genomics Research Core
The Genomics Research Core is equipped with state-of-the-art instrumentation and provides a variety of standard as well as customized genomic analyses to University researchers. The services include Sanger DNA sequencing, Next Generation sequencing of DNA and RNA, RNA/DNA extraction, purification and QC services, gene expression microarrays, whole transcriptome human and mouse microarrays, miRNA microarrays, TaqMan real-time PCR and Nanostring digital expression profiling for mRNA and miRNA, candidate gene and whole genome SNP array genotyping and NanoString CNV analysis. New technology and capabilities are added frequently; for a complete description of services and pricing, please visit the website.
The laboratory staff and leadership are available to provide expert advice and support with experimental design, new protocol development, technical support, data analysis and interpretation and assistance with manuscript and grant preparation including budgeting related to Genomics Research Core Services.
Health Sciences Core Research Facilities
The Health Sciences Core Research Facilities (HSCRF) were established through the Office of the Senior Vice Chancellor, Health Sciences in recognition of the vital role that centralized research resources play in the academic research enterprise. The technology required to perform innovative biomedical research changes rapidly and centralized research resources provide access to expertise, technology applications, and state-of-the-art instruments that are otherwise unavailable to most investigators.
Our research resource facilities include scientists and technicians who provide expert advice for study design, standard and custom applications and assist the investigator to take their project aims from conception to data production. The scientific leadership is available to work with you to adapt and apply methods appropriate to your scientific goals and assure that the interpretation of the results is supported by the data.
- Biomedical Mass Spectrometry Center (Proteomics, Metabolomics & other)
- Genomics Analysis Core (Bioinformatics)
- Genomics Research Core (RNA, DNA, Nextgen Sequencing)
- Health Sciences Sequencing Core at Children's Hospital of Pittsburgh (Illumina sequencing)
- Health Sciences Tissue Bank
- Hillman Live Cell Imaging Core (DNA damage, confocal microscopy)
- Peptide and Peptoid Synthesis Core
- Small Molecule Biomarker Core (Quantitative Mass Spectrometry analysis)
Health Sciences Library System (HSLS)
The Health Sciences Library System (HSLS) at the University of Pittsburgh offers a wide array of information services, educational opportunities, and resources in print and electronic format to faculty, students and researchers in the Schools of the Health Sciences. The HSLS web site is the primary access point for library information.
HSLS offers access to at thousands of databases and full-text electronic journals and books. Consult PITTCat for the Health Sciences for complete information about HSLS print and electronic resources.
Arrange an individualized consultation with a reference librarian. A consult could include any of the following: developing/refining a complicated search strategy, locating an appropriate electronic resource, advice on how to approach a difficult topic, data management concerns, systematic review assistance, IACUC searches, or techniques for using the Web to locate specific information. Contact the information services department or call 412-648-8866.
Molecular Biology Information Service:
Provides bioinformatics support via workshops, videos, access to data analysis software, consultations, and a comprehensive Web site. For further information contact Dr. Carrie Iwema, 412-383-6887 or Dr. Ansuman Chattopadhyay, 412-648-1297.
Health Sciences Sequencing Core at Children's Hospital of Pittsburgh
The Health Sciences Sequencing Core at Children’s Hospital of Pittsburgh (HSSCatCHP) offers Illumina next generation sequencing services to the University of Pittsburgh research community. The core was established by a cooperative agreement between the University of Pittsburgh Schools of Health Sciences and the Children’s Hospital of Pittsburgh of UPMC.
Our personnel are experts in next generation sequencing technologies and are committed to remaining abreast of advances that will impact the research effort of investigators. We encourage you to contact our core managers Debby Hollingshead and William Horne to arrange for a consultation. Our staff is available to share their experience and expertise to assist with development of projects of all sizes, standard or custom assay design, and other specialized application needs.
Health Sciences Tissue Bank (HSTB)
The HSTB provides University of Pittsburgh researchers with excess tissue materials obtained from clinical procedures performed at some of the University of Pittsburgh Medical Center (UPMC) hospitals. The main purposes of the HSTB are: (1) to provide a mechanism to simplify and streamline the process of research tissue accrual, storage and disbursement and (2) to provide efficient research pathology support services.
Services provided by HSTB include:
- Human tissue and biological specimen procurement services
- Honest broker services
- Research histology services
- Annotation of clinical data
- Tissue microarray (TMA) services
The HSTB contains a variety of solid tissues, cell aspirates, blood, peripheral blood mononuclear cells, as well as other clinical samples. Solid tissues are available from an assortment of tumors and from various non-neoplastic disease states from sources including the gastrointestinal tract, liver, and lung.
True normal tissues procured for approved projects through a working relationship with the Center for Organ Recovery and Education (CORE) are also available. The HSTB develops procurement strategies on an ongoing basis for projects requiring tissue types or disease states that are not currently being collected. This effort includes working directly with investigators as an interface with clinics, surgical programs and the HSTB Rapid Autopsy Program.
The HSTB has IRB approval for a variety of collections including a specific HSTB IRB to collect tissues that would have otherwise been discarded. The HSTB provides service based on the existing HSTB IRB protocol if appropriate; it can assist investigators with submission of their own IRB protocols, when necessary.
Health Sciences Web Portal
The University of Pittsburgh Schools of the Health Sciences sponsors this website. The purposes of the site are:
- to provide a starting point for access to educational and research-related activities in the health sciences community at Pitt and the UPMC,
- to make available information on health sciences research-related activities, including providing information on funding opportunities,
- to provide a starting point to additional Internet-based, health sciences related resources,
- to provide information about events happening across the Schools of the Health Sciences and the UPMC,
- to serve as a gateway for the health sciences community to University web sites that are of practical interest, and
- to alert the health sciences community to scientific news of interest and other important announcements.
Human Stem Cell Research Oversight Office
The primary purpose of the University of Pittsburgh’s hSCRO Committee is to ensure that all federal and Commonwealth of Pennsylvania regulations governing the conduct of human embryonic stem cell research are met and that other human stem cell research is conducted in accordance with the general principles expressed in the National Academies’ Guidelines for Human Embryonic Stem Cell Research, with the policies and procedures adopted by the hSCRO Committee, and with other relevant University of Pittsburgh research policies. Human embryonic stem cell research conducted at the University must also comply with the applicable NIH Guidelines for Human Stem Cell Research.
As there may be potential ethical concerns with any pluripotent stem cell research, the hSCRO Committee’s purview includes oversight of both embryonic and certain types of non-embryonic stem cell research. The hSCRO Committee’s specialized expertise and knowledge of the broad scope of human stem cell research being conducted at the University of Pittsburgh allows the Committee to serve as a valuable resource.
Institutional Animal Care and Use Committee
The University of Pittsburgh Institutional Animal Care and Use Committee (IACUC) oversees the university's animal programs, facilities and procedures insuring the appropriate care, use, and humane treatments of animals being used for research, testing and education. The IACUC serves as a resource to faculty, investigators, technicians, students, staff, and administrators, providing guidance in fulfilling the obligation to plan and conduct all animal use procedures with the highest scientific, humane, and ethical principles.
Institutional Biosafety Committee
The University of Pittsburgh Institutional Biosafety (IBC) Committee is responsible for reviewing and ensuring compliance with the NIH Guidelines on all research activities that involve recombinant DNA (rDNA) including human gene transfer clinical trials.
For guidance on export of dual-use research items, please contact the Office of Research.